AFM Education AFM IntroductionAFM BasicsApplication NotesNanotheaterResearcher Echo AFM Solutions BioScope Catalyst MultiMode V PicoForce BioScope SZ AFM Resources Events & News Scientific PapersRelated PublicationsTips & TricksGlossaryHelpful Links

Scientific Papers

I Liashkovich, W Hafezi, JE Kühn, H Oberleithner, A Kramer, V Shahin

"Exceptional mechanical and structural stability of herpes simplex virus type 1 unveiled with atomic force microscopy in fluid"
"Journal of Cell Science".
Accepted

A. Fabian, T. Fortmann, P. Dieterich, C. Riethmüller, P. Schön, S. Mally, B. Nilius
and A. Schwab
“TRPC1 channels regulate directionality of migrating cells”
Pflugers Archiv-European Journal of Physiology

Klyszejko, A.L., Shastri, S., Mari, S.A., Grubmuller, H., Muller, D.J., and Glaubitz, C. (2008) Folding and assembly of proteorhodopsin. J. Mol. Biol. 376(1), 35-41.

Sun, Z., Martinez-Lemus, L.A., Hill, M.A., and Meininger, G. (2008) Extracellular Matrix Specific Focal Adhesions in Vascular Smooth Muscle Produce Mechanically Active Adhesion Sites. Am. J. Physiol. Cell Physiol. In Press.

Na, S., Trache, A., Trzeciakowski, J, Sun, Z., Meininger, G., and Humphrey, J.D. (2008) Time-dependent changes in smooth muscle cell stiffness and focal adhesion area in response to cyclic equibiaxial stretch. Ann. Biomed. Eng. In Press.

Dague E, Delcorte A, Latgé JP, Dufrêne YF.
Combined use of atomic force microscopy, X-ray photoelectron spectroscopy, and secondary ion mass spectrometry for cell surface analysis.
Langmuir. 2008 Apr 1;24(7):2955-9.

Alsteens D, Verbelen C, Dague E, Raze D, Baulard AR, Dufrêne YF.
Organization of the mycobacterial cell wall: a nanoscale view.
Pflugers Arch. 2008 Apr;456(1):117-25.

Kramer A, Liashkovich I, Ludwig Y, Shahin V.
Atomic force microscopy visualises a hydrophobic meshwork in the central channel of the nuclear pore.
Pflugers Arch. 2008 Apr;456(1):155-62. Epub 2007 Dec 4.

Lassiter JB, Aizpurua J, Hernandez LI, Brandl DW, Romero I, Lal S, Hafner JH, Nordlander P, Halas NJ.
Close encounters between two nanoshells.
Nano Lett. 2008 Apr;8(4):1212-8. Epub 2008 Mar 18.
PMID: 18345644 [PubMed]

Shaw JE, Epand RF, Hsu JC, Mo GC, Epand RM, Yip CM.
Cationic peptide-induced remodelling of model membranes: direct visualization by in situ atomic force microscopy.
J Struct Biol. 2008 Apr;162(1):121-38. Epub 2007 Nov 17.

Blanco EM, Horton MA, Mesquida P.
Simultaneous investigation of the influence of topography and charge on protein adsorption using artificial nanopatterns.
Langmuir. 2008 Mar 18;24(6):2284-7. Epub 2008 Feb 16.

El Kirat K, Duprès V, Dufrêne YF.
Blistering of supported lipid membranes induced by Phospholipase D, as observed by real-time atomic force microscopy.
Biochim Biophys Acta. 2008 Jan;1778(1):276-82.

Riethmüller C, Oberleithner H, Wilhelmi M, Franz J, Schlatter E, Klokkers J, Edemir B.
Translocation of aquaporin-containing vesicles to the plasma membrane is facilitated by actomyosin relaxation.
Biophys J. 2008 Jan 15;94(2):671-8. Epub 2007 Nov 2.

Kreplak, L., Wang, H., Aebi, U., and Kong, X.-P. (2007) Atomic force microsopy of Mammalian urothelial surface. J. Mol. Biol. 374(2), 365-73.

Lim, R.Y., Koser, J., Huang, N.P., Schwarz-Herion, K., and Aebi, U. (2007) Nanomechanical interactions of phenylalanine-glycine nucleoporins studied by single molecule force-volume spectroscopy. J. Struc. Biol. 159(2), 277-89.

Elie-Caille, C., Severin, F., Helenius, J., Howard, J., Muller, D.J., and Hyman, A.A. (2007) Straight GDP-tubulin protofilaments form in the presence of taxol. Curr. Biol. 17(20), 1765-70.

Pogoryelov, D., Reichen, C., Klyszejko, A.L., Brunisholz, R., Muller, D.J., Dimroth, P., and Meier, T. (2007) The oligomeric state of C rings from cynobacterial F-ATP synthases varies from 13 to 15. J. Bacteriol. 189(16), 5895-902.

Park, P.S., Sapra, K.Y., Kolinski, M., Filipek, S., Palczewski, K., and Muller, D.J. (2007) Stabilizing effect of Zn2+ in native bovine rhodopsin. J. Biol. Chem. 282(15), 11377-85.

Xu, S., Dong, M., Liu, X., Howard, K.A., Kjems, J., and Besenbacher, F. (2007) Direct force measurements between siRNA and chitosan molecules using force spectroscopy. Biophys. J. 93(3), 952-9.

Dong, M., Xu, S., Oliveira, C.L., Pedersen, J.S., Thiel, S., Besenbacher, F., and Vorup-Jensen, T. (2007) Conformational changes in mannan-binding lectin bound to ligand surfaces.  J. Immunol. 178(5), 3016-22.

Shlyakhtenko, L.S., Gilmore, J., Portillo, A., Tamulaitis, G., Siksnys, V., and Lyubchenko, Y.L. (2007) Direct Visialization of the EcoRII-DNA triple synaptic complex by atomic force microscopy. Biochem. 46(39), 11128-36.

Engler AJ, Rehfeldt F, Sen S, Discher DE.
Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation.
Methods Cell Biol. 2007;83:521-45.

Hamon, L., Pastre, D., Dupaigne, P., Le Breton, C., Le Cam, E., and Pietrement, O. (2007) High-resolution AFM imaging of single-stranded DNA-binding (SSB) protein-DNA complexes. Nucl. Acids Res. 35(8), e58.

Scheuring S, Buzhynskyy N, Jaroslawski S, Gonçalves RP, Hite RK, Walz T.
Structural models of the supramolecular organization of AQP0 and connexons in junctional microdomains.
J Struct Biol. 2007 Dec;160(3):385-94. Epub 2007 Jul 28.

Buzhynskyy N, Girmens JF, Faigle W, Scheuring S.
Human cataract lens membrane at subnanometer resolution.
J Mol Biol. 2007 Nov 16;374(1):162-9. Epub 2007 Sep 14

Dague E, Alsteens D, Latgé JP, Verbelen C, Raze D, Baulard AR, Dufrêne YF.
Chemical force microscopy of single live cells.
Nano Lett. 2007 Oct;7(10):3026-30.

Alattia JR, Shaw JE, Yip CM, Privé GG.
Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C.
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17394-9. Epub 2007 Oct 22.

Oberleithner H, Riethmüller C, Schillers H, MacGregor G, de Wardener HE, Hausberg M.
Plasma sodium stiffens vascular endothelium and reduces nitric oxide release.
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16281-6.

Cross SE, Kreth J, Zhu L, Sullivan R, Shi W, Qi F, Gimzewski JK.
Nanomechanical properties of glucans and associated cell-surface adhesion of Streptococcus mutans probed by atomic force microscopy under in situ conditions.
Microbiology. 2007 Sep;153(Pt 9):3124-32

Johnson CP, Tang HY, Carag C, Speicher DW, Discher DE.
Forced unfolding of proteins within cells.
Science. 2007 Aug 3;317(5838):663-6

Plomp M, Leighton TJ, Wheeler KE, Hill HD, Malkin AJ.
In vitro high-resolution structural dynamics of single germinating bacterial spores.
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9644-9. Epub 2007 May 29.

Yang Y, Mayer KM, Hafner JH.
Quantitative membrane electrostatics with the atomic force microscope.
Biophys J. 2007 Mar 15;92(6):1966-74. Epub 2006 Dec 8.

Kessler, M. and Gaub, H. (2006) Unfolding barriers in bacteriorhodopsin probed from the cytoplasmic side and extracellular side by AFM. Structure. 14(3), 521-7.

Kessler, M., Gottschalk, K.E., Janovjak, H., Muller, D.J., and Gaub, H.E. (2006) Bacteriorhodopsin folds into the membrane against an external force. J. Mol. Biol. 357(2), 644-54.

Mikheikin, A.L., Lushnikov, A.Y., and Lyubchenko, Y.L. (2006) Effect of DNA supercoiling on the geometry of holliday junctions. Biochem. 45(43), 12998-3006.

Wojcikiewicz EP, Abdulreda MH, Zhang X, Moy VT.
Force spectroscopy of LFA-1 and its ligands, ICAM-1 and ICAM-2.
Biomacromolecules. 2006 Nov;7(11):3188-95

Milhiet PE, Gubellini F, Berquand A, Dosset P, Rigaud JL, Le Grimellec C, Lévy D.
High-resolution AFM of membrane proteins directly incorporated at high density in planar lipid bilayer.
Biophys J. 2006 Nov 1;91(9):3268-75. Epub 2006 Aug 11.

Alattia JR, Shaw JE, Yip CM, Privé GG
Direct visualization of saposin remodelling of lipid bilayers.
J Mol Biol. 2006 Oct 6;362(5):943-53. Epub 2006 Aug 9.

Fantner GE, Schitter G, Kindt JH, Ivanov T, Ivanova K, Patel R, Holten-Andersen N, Adams J, Thurner PJ, Rangelow IW, Hansma PK.
Components for high speed atomic force microscopy.
Ultramicroscopy. 2006 Jun-Jul;106(8-9):881-7. Epub 2006 Apr 27.

Hinterdorfer P, Dufrêne YF.
Detection and localization of single molecular recognition events using atomic force microscopy.
Nat Methods. 2006 May;3(5):347-55. Review

Scheuring S, Gonçalves RP, Prima V, Sturgis JN.
The photosynthetic apparatus of Rhodopseudomonas palustris: structures and organization.
J Mol Biol. 2006 Apr 21;358(1):83-96. Epub 2006 Feb 9.

Reichlin, T., Wild, A., Durrenberger, M., Daniels, A.U., Aebi, U., Hunziker, P.R. and Stolz, M. (2005) Investigating native coronary artery endothelium in situ and in cell culture by scanning force microscopy. J. Struc. Biol. 152(1), 52-63.

Trache, A., and Meininger, G.A. (2005) Atomic force-multi-optical imaging integrated microscope for monitoring molecular dynamics in live cells. J. Biomed. Opt. 10(6), 064023.

McAllister, C., Karymov, M.A., Kawano, Y., Lushnikov, A.Y., Mikheikin, A., Uversky, V.U., and Lyubchenko, Y.L. (2005) Protein Interactions and Misfolding Analyzed by AFM Force Spectroscopy. J. Mol. Biol. 354(5), 1028-42.

Eibl RH, Moy VT.
Atomic force microscopy measurements of protein-ligand interactions on living cells.
Methods Mol Biol. 2005;305:439-50

Malkin AJ, Plomp M, McPherson A.
Unraveling the architecture of viruses by high-resolution atomic force microscopy.
Methods Mol Biol. 2005;292:85-108.

Fantner GE, Hassenkam T, Kindt JH, Weaver JC, Birkedal H, Pechenik L, Cutroni JA, Cidade GA, Stucky GD, Morse DE, Hansma PK.
Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture.
Nat Mater. 2005 Aug;4(8):612-6. Epub 2005 Jul 17.
PMID: 16025123 [PubMed - indexed for MEDLINE:

Pelling AE, Li Y, Shi W, Gimzewski JK.
Nanoscale visualization and characterization of Myxococcus xanthus cells with atomic force microscopy.
Proc Natl Acad Sci U S A. 2005 May 3;102(18):6484-9. Epub 2005 Apr 19

Richter RP, Brisson AR.
Following the formation of supported lipid bilayers on mica: a study combining AFM, QCM-D, and ellipsometry.
Biophys J. 2005 May;88(5):3422-33. Epub 2005 Feb 24.

Kuznetsov YG, Gurnon JR, Van Etten JL, McPherson A.
Atomic force microscopy investigation of a chlorella virus, PBCV-1.
J Struct Biol. 2005 Mar;149(3):256-63.

Kuznetsov YG, Daijogo S, Zhou J, Semler BL, McPherson A.
Atomic force microscopy analysis of icosahedral virus RNA.
J Mol Biol. 2005 Mar 18;347(1):41-52. Epub 2005 Jan 19.

Sarkar, A., Robertson, R.B., and Fernandez, J.M. (2004) Simultaneous atomic force microscope and fluorescence measurements of protein unfolding using a calibrated evanescent wave. PNAS. 101(35), 12882-6.

Garcia, R.A. and Godwin, H.A. (2004) High Metal Concentrations are required for Self-Association of Synaptoagmin II. Biophys. J. 86, 2455-66.

Giocondi MC, Boichot S, Plénat T, Le Grimellec CC.
Structural diversity of sphingomyelin microdomains
Ultramicroscopy. 2004 Aug;100(3-4):135-43.

Richter RP, Brisson A.
QCM-D on mica for parallel QCM-D-AFM studies.
Langmuir. 2004 May 25;20(11):4609-13.

Giocondi MC, Milhiet PE, Dosset P, Le Grimellec C.
Use of cyclodextrin for AFM monitoring of model raft formation.
Biophys J. 2004 Feb;86(2):861-9.    
     
Eckel, R., Ros, R., Wilking, S.D., Sewald, N., and Anselmetti, D. (2003) Identification of Binding Mechanisms in Single Molecule-DNA Complexes. Biophys. J. 85, 1968-73.

Pastre, D., Pietrement, O., Fusil, S., Landousy, F., Jeusset, J., David, M.-O., Hamon, L., Le Cam, E., and Zozime, A. (2003) Adsorption of DNA to Mica Mediated by Divalent Counterions: A Theoretical and Experimental Study. Biophys. J. 85, 2507-18.

Sitko, J.C., Mateescu, E.M., and Hansma, H.G. (2003) Sequence-Dependent DNa Condensation and the Electrostatic Zipper. Biophys. J. 84, 419-31.

Bartels, F.W., Baumgarth, B., Anselmetti, D., Ros, R., and Beker, A. (2003) Specific binding of the regulatory protein ExpG to promoter regions of the galactoglucan biosynthesis gene cluster of Sinorhizobium meliloti – a combined molecular biology and force spectroscopy investigation. J. Struc. Biol. 143(2), 145-52.

Richter R, Mukhopadhyay A, Brisson A
Pathways of lipid vesicle deposition on solid surfaces: a combined QCM-D and AFM study.
Biophys J. 2003 Nov;85(5):3035-47.

Malkin AJ, McPherson A, Gershon PD.
Structure of intracellular mature vaccinia virus visualized by in situ atomic force microscopy.
J Virol. 2003 Jun;77(11):6332-40.

Müller DJ, Engel A, Matthey U, Meier T, Dimroth P, Suda K.
Observing membrane protein diffusion at subnanometer resolution.
J Mol Biol. 2003 Apr 11;327(5):925-30.

Muller, D.J., Kessler, M., Oesterhelt, F., Moller, C., Oesterhelt, D., and Gaub, H. (2002) Stability of bacteriorhodopsin alpha-helices and loops analyzed by single-molecule force spectroscopy. Biophys. J. 83(6), 3578-88.

Müller DJ, Hand GM, Engel A, Sosinsky GE.
Conformational changes in surface structures of isolated connexin 26 gap junctions.
EMBO J. 2002 Jul 15;21(14):3598-607.

Oroudjev, E., Soares, J., Arcidiancono, S., Thompson, J.B., Fossey, S.A., and Hansma, H.G. (2002) egmented nanofibers of spider dragline silk: Atomic force microscopy and single-molecule spectroscopy. PNAS. 99(2), 6460-65.

Hilde A. Rinia, Margot M. E. Snel, Jan P. J. M. van der Eerden, Ben de Kruijff
Striated domains: self-organizing ordered assemblies of transmembrane alpha-helical peptides and lipids in bilayers.
FEBS Letters 2001, 1: 92-96

Jarchow, J., Fritz, J., Anselmetti, D., Calabro, A., Hascall, V.C., Gerosa, D., Burger, M.M., and Fernandez-Busquets. (2000) Supramolecular Structure of a New Family of Circular Prteoglycans Mediating Cell Adhesion in Sponges. J. Struc. Biol. 132, 95-105.

Reviakine I., Bergsma-Schutter W., Mazères-Dubut C., Govorukhina N., Alain Brisson
Surface Topography of the p3 and p6 Annexin V Crystal Forms Determined by Atomic Force Microscopy
J. Struct. Biol. 2000: 131: 234-239.

Petsev DN, Thomas BR, Yau S, Vekilov PG.
Interactions and aggregation of apoferritin molecules in solution: effects of added electrolytes.
Biophys J. 2000 Apr;78(4):2060-9.

San Paulo, A. and Garcia, R. A. (2000) High-resolution Imaging of Antibodies by Tapping-Mode Atomic Force Microscopy: Attractive and Repulsive Tip-Sample Interaction Regimes. Biophys. J. 78, 1599-605.

Fritz, J., Katopodis, A.G., Kolbinger, F., and Anselmetti, D. (1998) Force-mediated kinetics of single P-selectin/ligand complexes observed by atomic force microscopy. PNAS. 95(21), 12283-8.

Laney, D.E., Garcia, R.A., Parsons, S.M., and Hansma, H.G. (1997) Changes in the Elastic Properties of Cholinergic Synaptic Vesicles as Measured by Atomic Force Microscopy. Biophys. J. 72, 806-13.

Hansma, H.G., Sinsheimer, R.L., Min-Qian, L., and Hansma, P.K. (1992) Atomic force microscopy of single- and double-stranded DNA. Nucl. Acids Res. 20(14), 3585-90.